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Mycobacterium Leprae Binds to a 25-KDa Phosphorylated Glycoprotein of Human Peripheral Nerve |
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| Authors: | Suneetha Lavanya M. Satish Posettihalli R. Korula Ravi J. Suneetha Sujai K. Job Charles K. Balasubramanian Aiylam S. |
| Affiliation: | (1) Neurochemistry Laboratory, Department of Neurological Sciences, India;(2) Department of Orthopaedics, Christian Medical College and Hospital, Vellore—, 632 004, TN, India;(3) Schieffelin Leprosy Research Centre, Karigiri, 632 106, TN, India;(4) St. Thomas Hospital and Leprosy Centre, Chettupattu 606 801, TN, India |
| Abstract: | Mycobacterium leprae, the causative agent of leprosy, specifically invades and destroys the peripheral nerve, which results in the main clinical manifestation of the disease. Little is known about the bacteria—nerve protein interaction. We show in the present work that M leprae binds to a 25 kDa glycoprotein from human peripheral nerve. This protein is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy. |
| Keywords: | Human peripheral nerve protein phosphorylation Mycobacterium leprae binding protein |
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