Database for queries of melanoma cohorts with molecular and clinical data |
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| Authors: | Manuel Philip Sven Holger Puppel Mathias Stiller Annette Paschen Alexander Roesch Anne Zaremba Dirk Schadendorf Susanne Horn |
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| Affiliation: | 1. Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium (DKTK) partner site Essen/Düsseldorf, Essen, Germany;2. Rudolf-Schönheimer-Institute of Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany;3. Division Molecular Pathology, Institute of Pathology, University Hospital Leipzig, Leipzig, Germany |
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| Abstract: | Large genome-scale studies are deposited in various public sequence repositories. However, their access and analysis can be non-trivial to infrequent users. Here, we present a new database connecting whole transcriptomes with clinical data for straight-forward access and analysis of patient-specific samples. Users can perform association tests of survival and gene expression across different cohorts, identify cell-type expressions, or correlate the presence of immune cells. In summary, we present a new data hub for bench scientists to perform replication and discovery studies. |
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| Keywords: | data integration immune checkpoint inhibition immune infiltration melanoma RNA-seq |
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