The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration |
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Authors: | Hamish TJ Gilbert Judith A Hoyland Anthony J Freemont Sarah J Millward-Sadler |
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Institution: | (1) Regenerative Medicine, Faculty of Medical and Human Sciences, School of Biomedicine, University of Manchester, Stopford Building, Oxford Road, M13 9PL Manchester, UK |
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Abstract: | Introduction Recent evidence suggests that intervertebral disc (IVD) cells derived from degenerative tissue are unable to respond to physiologically
relevant mechanical stimuli in the 'normal' anabolic manner, but instead respond by increasing matrix catabolism. Understanding
the nature of the biological processes which allow disc cells to sense and respond to mechanical stimuli (a process termed
'mechanotransduction') is important to ascertain whether these signalling pathways differ with disease. The aim here was to
investigate the involvement of interleukin (IL)-1 and IL-4 in the response of annulus fibrosus (AF) cells derived from nondegenerative
and degenerative tissue to cyclic tensile strain to determine whether cytokine involvement differed with IVD degeneration. |
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Keywords: | |
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