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Xanthone C-glycosides isomers purified from Dryopteris ramosa (Hope) C. Chr. with bactericidal and cytotoxic prospects |
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| Institution: | 1. Department of Botany, PMAS-Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan;2. Department of Statistics & Mathematics, PMAS-Arid Agriculture University Rawalpindi, Rawalpindi 46300, Pakistan;3. Department of General Sciences, Prince Sultan University, Rafha Street, Riyadh, Saudi Arabia;4. Department of Agronomy, The University of Haripur, Haripur 22620, Pakistan;5. Department of Microbiology, The University of Haripur, Haripur 22620, Pakistan |
| Abstract: | Xanthones C-glycosides are plants secondary metabolites with diverse biological activities. Among the C-glycoside xanthones, the mangiferin (MF) is of widespread occurrence in plants while isomangiferin (IsoMF) is not very common. For the present study mangiferin (MF) and isomangiferin (IsoMF) were isolated from Dryopteris ramosa. The antibacterial potential of MF and IsoMF was evaluated by using agar well diffusion method while cytotoxic properties of MF and IsoMF were assessed by brine shrimp lethality test (BSLT). The antibacterial potential of MF and IsoMF increases in dose dependent manner. The minimum inhibitory concentration (MIC) indicated strong antibacterial potential of MF against Salmonella setubal (125 µg/mL) and Bacillus subtilis (125 µg/mL) while MF showed weak antibacterial potential against Escherichia coli (500 µg/mL). On the other hand the IsoMF showed better antibacterial potential against all the tested strain including Escherichia coli (MIC = 250 µg/mL). The MF and IsoMF showed poor cytotoxicity towards Brine shrimp nauplii as indicated by their LD50 (969.77 ± 0.67 and 768.92 ± 0.81 µg/mL respectively). The present study has highlighted the antibacterial potential of MF and IsoMF. Further evaluation of these two isomeric compounds may prove to be the future remedies for various bacterial infections and other human ailments. |
| Keywords: | Antibacterial Mangiferin Isomangiferin Xanthone C-glycosides cytotoxic ATCC"} {"#name":"keyword" "$":{"id":"k0045"} "$$":[{"#name":"text" "_":"American type cell culture BSLT"} {"#name":"keyword" "$":{"id":"k0055"} "$$":[{"#name":"text" "_":"Brine shrimp lethality test CFU"} {"#name":"keyword" "$":{"id":"k0065"} "$$":[{"#name":"text" "_":"Colony forming units DMSO"} {"#name":"keyword" "$":{"id":"k0075"} "$$":[{"#name":"text" "_":"Dimethyl sulfoxide IsoMF"} {"#name":"keyword" "$":{"id":"k0085"} "$$":[{"#name":"text" "_":"Isomangiferin LD"} {"#name":"keyword" "$":{"id":"k0095"} "$$":[{"#name":"text" "_":"Lethal dose MF"} {"#name":"keyword" "$":{"id":"k0105"} "$$":[{"#name":"text" "_":"Mangiferin MIC"} {"#name":"keyword" "$":{"id":"k0115"} "$$":[{"#name":"text" "_":"Minimum inhibitory concentration Nic"} {"#name":"keyword" "$":{"id":"k0125"} "$$":[{"#name":"text" "_":"Nicotine |
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