Enteric pathogens modulate metabolic homeostasis in the Drosophila melanogaster host |
| |
| Affiliation: | 1. Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar;2. Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar;3. Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar;4. Biomedical Research Center, Qatar University, Doha, Qatar;1. Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;2. Health Sciences Unit, Faculty of Social Sciences, Tampere University, Tampere, Finland;3. HPGC Research Group, Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran;4. Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, USA;5. Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran;6. Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, Tehran, Iran;7. Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran;1. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Center for Biosafety Mega-Science, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China;2. Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China;3. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China;1. Dept. Infection Biology, Institute of Infection and Global Health, University of Liverpool, L3 5RF, UK;2. Centre Eugène Marquis, Université Rennes-1, INSERM U1242, Rennes, France;3. Graduate Studies Office, Department of Research, Innovation and Graduate Studies, Waterford Institute of Technology, X91 K0EK, Ireland;1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences (AMMS), Beijing, China;2. Department of Infectious Medicine, Beijing Children''s Hospital, Capital Medical University, National Center for Children''s Health, Beijing, China |
| |
| Abstract: | On quotidian basis, living beings work out an armistice with their microbial flora and a scuffle with invading pathogens to maintain a normal state of health. Although producing virulence factors and escaping the host's immune machinery are the paramount tools used by pathogens in their “arm race” against the host; here, we provide insight into another facet of pathogenic embitterment by presenting evidence of the ability of enteric pathogens to exhibit pathogenicity through modulating metabolic homeostasis in Drosophila melanogaster. We report that Escherichia coli and Shigella sonnei orally infected flies exhibit lipid droplet deprivation from the fat body, irregular accumulation of lipid droplets in the midgut, and significant elevation of systemic glucose and triglyceride levels. Our findings indicate that these detected metabolic alterations in infected flies could be attributed to differential regulation of peptide hormones known to be crucial for lipid metabolism and insulin signaling. Gaining a proper understanding of infection-induced alterations succours in curbing the pathogenesis of enteric diseases and sets the stage for promising therapeutic approaches to quarry infection-induced metabolic disorders. |
| |
| Keywords: | Enteric pathogens Metabolic alterations Peptide hormones |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
