Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors |
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| Authors: | Sano Hiroko Noguchi Tomomi Miyajima Atsushi Hashimoto Yuichi Miyachi Hiroyuki |
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| Institution: | Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
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| Abstract: | Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs). |
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