Large increase in disulphide bonds containing cytosol proteins after chronic cadmium administration, estimated in isolated rat liver cells |
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| Authors: | A. F. W. Morselt C. J. A. van de Hamer L. Prinsen E. J. Jongstra-Spaapen J. H. J. Copius Peereboom-Stegeman K. S. Bosch |
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| Affiliation: | (1) Laboratory for Histology and Cell Biology, University of Amsterdam, Academic Medical Centre, Meibergdreef 15, NL-1105 AZ Amsterdam, The Netherlands;(2) Interuniversity Reactor Institute, Mekelweg 15, NL-2629 JB Delft, The Netherlands |
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| Abstract: | Summary Using histochemical staining, followed by cytophotometric quantitation of disulphide bonds and total protein in isolated liver cells of rats treated for a long time with low doses of CdCl2, a large increase in disulphide bonds containing proteins could be demonstrated in cells of one ploidy class. This increase seems to be due to an increase in high molecular weight (HMW) cytosol proteins as estimated biochemically. They probably represent polymers of metallothionein. |
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