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Vasopressin and oxytocin modulation of melatonin secretion from rat pineal glands |
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| Authors: | V Simonneaux A Ouichou JPH Burbach P Pvet |
| Institution: | a CNRS-URA 1332 “Neurobiologie des fonctions rythmiques et saisonnières,” Université Louis Pasteur 12 rue de l'Université, 67000, Strasbourg, France b Rudolf Magnus Institute, Medical Faculty, University of Utrecht, 3521 GD, Utrecht, The Netherlands |
| Abstract: | The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. Since vasopressin (VP)- and oxytocin (OT)-containing fibers innervate the pineal gland, the effects of VP and OT on melatonin release from perifused rat pineal glands were investigated. VP (10?7 M) and OT (10?6 M) decreased the basal melatonin secretion. No dose-dependent effect was observed. At high concentrations (10?5) these peptides potentiated the isoproterenol-induced increase of melatonin secretion. Below 10?5 M no potentiation was observed. Fragments of VP {pGlu4,Cys6]VP(4–9)} and OT {pGlu4,Cys6]OT(4–9)} did not display any effect on the isoproterenol-induced melatonin secretion. |
| Keywords: | Pineal gland Melatonin Perifusion Vasopressin Oxytocin |
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