Prostaglandin levels in endometrial jet wash specimens in patients with dysmenorrhea before and after indomethacin therapy |
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Authors: | David R Halbert Laurence M Demers John Fontana DE Darnell Jones |
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Institution: | aDepartments of Obstetrics and Gynecology and Pathology The M.S. Hershey Medical Center The Pennsylvania State University Hershey, Pennsylvania 17033, USA |
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Abstract: | A patient with functional primary dysmenorrhea of over two years duration was subjected to the endometrial jet wash technique during the period of active menstrual flow. Prostaglandin F analysis of the jet washings revealed significantly elevated levels during menstruation over normal control levels. Following indomethacin therapy, jet wash prostaglandin F levels were dramatically reduced and the patient became asymptomatic. A cause and effect relationship between prostaglandin F and dysmenorrhea is suggested by these studies |
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