B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. |
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Authors: | C Murre A Voronova and D Baltimore |
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Institution: | Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142. |
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Abstract: | Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development. |
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