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Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations
Authors:Valentina Cipriani  Anna Tierney  John R Griffiths  Verena Zuber  Panagiotis I Sergouniotis  John RW Yates  Anthony T Moore  Paul N Bishop  Simon J Clark  Richard D Unwin
Institution:1. William Harvey Research Institute, Queen Mary University of London, London, EC1M 6BQ, United Kingdom;2. UCL Institute of Ophthalmology, University College London, London, EC1V 9EL, United Kingdom;3. Moorfields Eye Hospital National Health Service Foundation Trust, London, EC1V 2PD, United Kingdom;4. UCL Genetics Institute, University College London, London, WC1E 6BT, United Kingdom;5. Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, M13 9NY, United Kingdom;6. Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, United Kingdom;7. Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, M13 9PT, United Kingdom;8. Manchester Centre for Genomic Medicine, Saint Mary’s Hospital, Manchester University National Health Service Foundation Trust, Manchester, M13 9WL, United Kingdom;9. Department of Medical Genetics, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom;10. Ophthalmology Department, University of California San Francisco, San Francisco, CA 94143-0730, USA;11. Manchester Royal Eye Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9WL, United Kingdom;12. University Eye Clinic, Department for Ophthalmology, Eberhard Karls University of Tübingen, Tübingen, Baden-Württemberg, 72076, Germany;13. Institute for Ophthalmic Research, Eberhard Karls University of Tübingen, Tübingen, Baden-Württemberg, 72076, Germany;14. Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, M13 9PT, UK;15. Stoller Biomarker Discovery Centre and Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, M13 9NQ, United Kingdom
Abstract:
Keywords:age-related macular degeneration  complement factor H  factor H-related  mass spectrometry  Mendelian randomization
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