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Bi-allelic mutations of DNAH10 cause primary male infertility with asthenoteratozoospermia in humans and mice
Authors:Chaofeng Tu  Jiangshan Cong  Qianjun Zhang  Xiaojin He  Rui Zheng  Xiaoxuan Yang  Yang Gao  Huan Wu  Mingrong Lv  Yayun Gu  Shuai Lu  Chunyu Liu  Shixiong Tian  Lanlan Meng  Weili Wang  Chen Tan  Hongchuan Nie  Dongyan Li  Huan Zhang  Fei Gong  Liang Hu  Guangxiu Lu  Wenming Xu  Ge Lin  Feng Zhang  Yunxia Cao  Yue-Qiu Tan
Affiliation:1. Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha 410000, China;2. Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410000, China;3. Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai 200011, China;4. Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai 200011, China;5. Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;6. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei 230032, China;7. Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People’s Republic of China, Hefei 230032, China;8. Department of Obstetrics/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China;9. State Key Laboratory of Reproductive Medicine, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Abstract:
Keywords:male infertility  MMAF  sperm flagella  knockout mice
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