Declining NAD Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging |
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| Authors: | Ana P. Gomes,Nathan L. Price,Alvin J.Y. Ling,Javid J. Moslehi,Magdalene K. Montgomery,Luis Rajman,James P. White,Joã o S. Teodoro,Christiane D. Wrann,Basil P. Hubbard,Evi M. Mercken,Carlos M. Palmeira,Rafael de Cabo,Anabela P. Rolo,Nigel Turner,Eric L. Bell,David A. Sinclair |
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| Affiliation: | 1 Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA;2 Center for Neurosciences and Cell Biology, 3004-517 Coimbra, Portugal;3 Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, 3004-517 Coimbra, Portugal;4 Department of Medical Oncology, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA;5 Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;6 Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney NSW 2052, Australia;7 Dana-Farber Cancer Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;8 Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA;9 Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal;10 Department of Biology, Massachusetts Institute of Technology, Paul F. Glenn Laboratory for the Science of Aging, Cambridge, MA 02139, USA |
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