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Evaluation of stability and size distribution of sunflower oil-coated micro bubbles for localized drug delivery |
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| Authors: | WalterDuartedeAraujo Filho Fábio Kurt Schneider Rigoberto EM Morales |
| Institution: | 1. Department of Orthopedic Surgery, Hannover Medical School, Anna-von-Borries-Str.1-7, 30625, Hannover, Germany 2. Institute of Production Engineering and Machine Tools (IFW), Leibnitz University of Hannover, Lise-Meitner-Str. 1, 30823, Garbsen, Germany 3. Institute for Inorganic Chemistry, Leibniz University of Hannover, Callinstr. 9, 30167, Hannover, Germany 4. Small Animal Clinic, School of Veterinary Medicine Hannover, Bischhofsholer Damm 15, 30173, Hannover, Germany 5. Clinic for Small Animal Surgery and Reproduction, Centre of Clinical Veterinary Medicine, Faculty of Veterinary Medicine Ludwig-Maximilians-Universit?t M??nchen, Veterin?rstr. 13, 80539, Munich, Germany 6. Institute of Materials Science, Leibniz University Hannover, An der Universit?t 2, 30823, Garbsen, Germany 7. Center for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Bismarckstr. 9-15, 69115, Heidelberg, Germany |
| Abstract: | BackgroundIn recent years magnesium alloys have been intensively investigated as potential resorbable materials with appropriate mechanical and corrosion properties. Particularly in orthopedic research magnesium is interesting because of its mechanical properties close to those of natural bone, the prevention of both stress shielding and removal of the implant after surgery.MethodsZEK100 plates were examined in this in vitro study with Hank's Balanced Salt Solution under physiological conditions with a constant laminar flow rate. After 14, 28 and 42 days of immersion the ZEK100 plates were mechanically tested via four point bending test. The surfaces of the immersed specimens were characterized by SEM, EDX and XRD.ResultsThe four point bending test displayed an increased bending strength after 6 weeks immersion compared to the 2 week group and 4 week group. The characterization of the surface revealed the presence of high amounts of O, P and Ca on the surface and small Mg content. This indicates the precipitation of calcium phosphates with low solubility on the surface of the ZEK100 plates.ConclusionsThe results of the present in vitro study indicate that ZEK100 is a potential candidate for degradable orthopedic implants. Further investigations are needed to examine the degradation behavior. |
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