The 25 kDa protein kinase inhibitor present in liver cell is absent in fast growing HTC cells and is induced in sodium butyrate treated cells |
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| Authors: | M Delpech F Lévy-Favatier L Tichonicky J Kruh |
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| Affiliation: | Faculté de Médecine Cochin-Port-royal, Institute De Pathologie Moléculaire, Unité Associée CNRS, 24, rue du Fg Saint-Jacques, 75014 Paris, France |
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| Abstract: | We have recently characterized a cAMP independent protein kinase inhibitor in rat liver. This inhibitor is absent or inactive in fast growing HTC cells and is induced according to exponential kinetics by sodium butyrate, a compound which arrests cell growth at the G1 phase of the cell cycle. It is suggested that the inhibitor could be involved in cell growth regulation. |
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