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The fungus Penicillium variabile Sopp 1912 isolated from permafrost deposits as a producer of rugulovasines |
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| Authors: | V. P. Zhelifonova T. V. Antipova S. M. Ozerskaya N. E. Ivanushkina A. G. Kozlovskii |
| Affiliation: | (1) Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pr. Nauki 5, Pushchino, Moscow oblast, 142290, Russia |
| Abstract: | It has been established that relict fungi Penicillium variabile Sopp can synthesize clavine alkaloids, rugulovasines A and B, which are revealed in this species for the first time. Submerged cultivation of the strain-producer revealed several microcycles of conidia formation. The synthesis of alkaloids was also of a cyclic character. The synchronism of cyclic rugulovasine biosynthesis and conidia formation was revealed. Zinc ions stimulated fungal growth but had a negative effect on the biosynthesis of rugulovasines. |
| Keywords: | filamentous fungi permafrost ancient deposits Penicillium microcycle conidiation biosynthesis secondary metabolites clavine alkaloids rugulovasines |
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