New hydrogen donor: a facile method for the removal of hydrogenolysable protecting groups in Peptide synthesis |
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Authors: | Gowda D Channe Mahesh B |
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Institution: | Department of Studies in Chemistry, University of Mysore, Manasagangotri, Karnataka, India. dcgowda@yahoo.com |
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Abstract: | Removal of some commonly used protecting groups in peptide synthesis by catalytic transfer hydrogenation employing hydrazinium monoformate and 10%Pd on carbon is described. This method is equally competitive with other methods in deblocking most of the commonly used protecting groups in peptide synthesis. tert-Butyl derived and base labile protecting groups were completely stable under these conditions. This is more effective than hydrazine or formic acid. |
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