Developmental expression profiles of axon guidance signaling and the immune system in the marmoset cortex: Potential molecular mechanisms of pruning of dendritic spines during primate synapse formation in late infancy and prepuberty (I) |
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| Authors: | Tetsuya Sasaki Tomofumi Oga Keiko Nakagaki Kazuhisa Sakai Kayo Sumida Kohei Hoshino Izuru Miyawaki Koichi Saito Fumikazu Suto Noritaka Ichinohe |
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| Institution: | 1. Department of Ultrastructural Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan;2. Graduate School of Frontier Biosciences, Osaka University, Toyonaka, Osaka 560-8531, Japan;3. Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-8558, Japan;4. Preclinical Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-0022, Japan |
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| Abstract: | The synapse number and the related dendritic spine number in the cerebral cortex of primates shows a rapid increase after birth. Depending on the brain region and species, the number of synapses reaches a peak before adulthood, and pruning takes place after this peak (overshoot-type synaptic formation). Human mental disorders, such as autism and schizophrenia, are hypothesized to be a result of either too weak or excessive pruning after the peak is reached. Thus, it is important to study the molecular mechanisms underlying overshoot-type synaptic formation, particularly the pruning phase. |
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| Keywords: | Primate Overshoot-type synapse formation Synaptic pruning Axon guidance signaling Microglia Complement |
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