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Over-expression of Oct4 and Sox2 transcription factors enhances differentiation of human umbilical cord blood cells in vivo
Authors:Daria Guseva,Albert A. Rizvanov,Ilnur I. Salafutdinov,Nezhdana V. Kudryashova,Andrá  s Palotá  s,Rustem R. Islamov
Affiliation:1. Kazan State Medical University, Kazan, Republic of Tatarstan, Russian Federation;2. Hannover Medical School, Hannover, Germany;3. Kazan Federal University, Kazan, Republic of Tatarstan, Russian Federation;4. Asklepios-Med (Private Medical Practice and Research Center), Szeged, Hungary
Abstract:Gene and cell-based therapies comprise innovative aspects of regenerative medicine. Even though stem cells represent a highly potential therapeutic strategy, their wide-spread exploitation is marred by ethical concerns, potential for malignant transformation and a plethora of other technical issues, largely restricting their use to experimental studies. Utilizing genetically modified human umbilical cord blood mono-nuclear cells (hUCB-MCs), this communication reports enhanced differentiation of transplants in a mouse model of amyotrophic lateral sclerosis (ALS). Over-expressing Oct4 and Sox2 induced production of neural marker PGP9.5, as well as transformation of hUCB-MCs into micro-glial and endothelial lines in ALS spinal cords. In addition to producing new nerve cells, providing degenerated areas with trophic factors and neo-vascularisation might prevent and even reverse progressive loss of moto-neurons and skeletal muscle paralysis.
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