Antibacterial diterpenoids from Jatropha podagrica Hook |
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Authors: | Aiyelaagbe Olapeju O Adesogan Kayode Ekundayo Olusegun Gloer James B |
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Affiliation: | Department of Chemistry, University of Ibadan, Ibadan, Nigeria. oaiyelaagbe@yahoo.com |
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Abstract: | Japodagrin (1) and japodagrone (2), two macrocylic diterpenoids possessing lathyrane and jatrophane skeletons, respectively, have been isolated from the root of Jatropha podagrica Hook. Four other diterpenoids (3-6) were also isolated from this plant. The structures of these compounds were elucidated on the basis of NMR and HRMS analysis, and by spectral comparisons. The compounds displayed antibacterial activity against some gram-positive bacteria. |
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