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| 宫颈脱落细胞中HCCR的表达及意义 | |
| 引用本文： | 崔艳艳,霍山,郭晓宁,李建华. 宫颈脱落细胞中HCCR的表达及意义[J]. 中国组织化学与细胞化学杂志, 2010, 19(1): 77-80 |
| 作者姓名： | 崔艳艳 霍山 郭晓宁 李建华 |
| 作者单位： | 1. 赤峰学院附属医院肿瘤内科 2. 赤峰市220医院,内蒙古,024000 3. 中国医科大学病理教研室及附属第一医院病理科,沈阳,110001 |
| 基金项目： | 辽宁省科学技术厅(2005225003) |
| 摘 要： | 目的研究人宫颈癌基因(HCCR)在宫颈脱落细胞中的表达情况,探讨其对宫颈癌及癌前病变诊断的意义。方法采用Western blot及免疫组化SP法对79例宫颈脱落细胞中HCCR蛋白进行检测,其中正常宫颈上皮脱落细胞11例、宫颈上皮内瘤样病变(CIN)53例、宫颈癌(CCa)15例。所有标本均来自中国医科大学附属第一医院。结果HCCR基因在正常宫颈脱落细胞中不表达或阳性率较低,在宫颈上皮内瘤变及宫颈癌中表达阳性率随病变加重而逐级升高。结论HCCR与宫颈上皮内瘤变及宫颈癌的发生密切相关,检测宫颈脱落细胞中HCCR蛋白的水平对宫颈癌的筛查和诊断可能具有重要意义。 |
| 关 键 词： | 宫颈脱落细胞 人宫颈癌蛋白 宫颈上皮内瘤变 宫颈癌 |
EXPRESSION AND SIGNIFICANCE OF HCCR IN CERVICAL EXFOLIATED CELLS |
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| Cui Yanyan,Huo Shan,Guo Xiaoning,Li Jianhua. EXPRESSION AND SIGNIFICANCE OF HCCR IN CERVICAL EXFOLIATED CELLS[J]. Chinese Journal of Histochemistry and Cytochemistry, 2010, 19(1): 77-80 | |
| Authors: | Cui Yanyan Huo Shan Guo Xiaoning Li Jianhua |
| Affiliation: | Medical Department of Oncology;Chifeng College Affiliated Hospital;1220Hospital;Chifeng;Inner Mongolia;024000;3Department of Pathology;The First Affiliated Hospital of China Medical University;Shenyang 110001;China |
| Abstract: | Objective To detect the expression of HCCR protein in cervical exfoliated cells for the diagnosis of cervical cancer and precancerous lesion.Methods By using Western blot and immunohistochemical SP analysis, HCCR protein was detected in 79 cases of cervical exfoliated cells, which consisted of 11 cases of normal cervical epithelium, 53 cases of Cervical intraepithelial neoplasm and 15 cases of cervical cancer. All samples came from The First Affiliated Hospital of China Medical University.Results HCCR showe... |
| Keywords: | Cervical exfoliated cell Human cervical cancer (HCCR) Cervical intraepithelial neoplasia Cervical cancer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |