| Hedgehog信号通路靶基因与肿瘤的关系之研究进展 |
| |
| 引用本文： | 程萍,郭传勇,徐选福.Hedgehog信号通路靶基因与肿瘤的关系之研究进展[J].现代生物医学进展,2013(32):6393-6395,6398. |
| |
| 作者姓名： | 程萍 郭传勇 徐选福 |
| |
| 作者单位： | 同济大学附属第十人民医院消化科,上海200072 |
| |
| 基金项目： | 国家自然科学基金项目（81270515;81072005;81172312）;上海市科委创新行动计划国际合作课题（11430702400） |
| |
| 摘 要： | Hedgehog（HH）蛋白属于分泌蛋白家族，广泛表达于哺乳动物，非哺乳动物等多个物种，参与调控多种肿瘤形成，器官成熟、血管生成，干细胞分化，免疫细胞以及胚胎发育。文章主要就近几年来国内外对hedgehog信号通道下游靶基因在肿瘤干细胞，肿瘤细胞的转移，增殖，凋亡及胚胎发育等方面的研究进展进行综述，重点阐述hedgehog信号通路下游靶基因与肿瘤及发育的关系，以期能为与hedgehog信号通道参与调控的相关疾病提供一些靶向性临床诊疗的新思路。
|
| 关 键 词： | Hedgehog信号通路 信号转导 肿瘤 胚胎发育 靶基因 |
Research Progress of the Hedgehog Signaling Pathway Target Genes and Tumor |
| |
| CHENG Ping,GUO Chuan-yong,XU Xuan-fu.Research Progress of the Hedgehog Signaling Pathway Target Genes and Tumor[J].Progress in Modern Biomedicine,2013(32):6393-6395,6398. |
| |
| Authors: | CHENG Ping GUO Chuan-yong XU Xuan-fu |
| |
| Institution: | (Department of Gastroenterology, Shanghai Tenth People＇s Hospital, Tongji University, Shanghai, 200072, China) |
| |
| Abstract: | Hedgehog （HH） protein belongs to a family of secreted proteins, which is widely expressed in mammals and non- mammals species and is involved in the regulation of a variety of tumor formation in mature organs, angiogenesis, stem cell differentiation, immune cells, and embryonic development. This articles is mainly about the research progress of the hedgehog signaling pathway down- stream target genes in cancer stem cells, tumor cell metastasis, proliferation, apoptosis and embryonic development in recent years on home and abroad. Here I review the connections between the hedgehog signaling pathway downstream target genes and tumor develop- ment. This may give us a new clinical idea of treat realated disease. |
| |
| Keywords: | Hedgehog signaling pathway Signal transduction Tumor Embryonic development Target genes |
| 本文献已被 维普 等数据库收录！ |
