贝那普利联合氨氯地平治疗原发性高血压的临床研究

目的：探讨贝那普利联合氨氯地平治疗原发性高血压的降压效果。方法：将152例原发性高血压患者随机分为两组，治疗组（n=76）采用贝那普利＋氨氯地平进行治疗，对照组（n=76）采用贝那普利进行治疗，疗程8周，在治疗前、治疗后4周和8周进行24h动态血压监测（ABPM），分别记录24h平均血压、白天及夜间平均血压、心率等指标，分析并比较临床疗效。结果：两组患者治疗前后24h平均血压、白天及夜间平均血压明显低于治疗前，差异具有显著性意义（P〈0．05）；治疗组和对照组总有效率分别为97．4％和80-3％，差异均具有显著性意义（P〈0．01）。结论：应用贝那普利＋氨氯地平对原发性高血压进行治疗，其降压效果明显，有效控制血压降低，不良反应少，是理想的联合降压方法，值得临床推荐。

Efficacy Analysis on Treatment of Primary Hypertension by Benazepril and Amlodipine

Objective： To investigate the efficiency of the clinical treatment of primary hypertension by benazepril and amlodipine. Methods： 152 PH patients were randomly divided into treatment group （n=76） which treated with benazepril and amlodipine, and control group （n=76） which treated with benazepril for 8 weeks. The two groups were monitored by 24h ambulatory blood pressure monitoring （ABPM） before treatment, at 4 weeks and 8 weeks. The 24h average blood pressure, day-time average blood pressure, night-time average blood pressure and heart rate were recorded and analyzed. Results： It was significantly different when comparing the 24h average blood pressure, day-time average blood pressure, night-time average blood pressure of the two groups （P〈0.05）. And the total efficiency of the treatment group and control group were 97.4% and 80.3%, respectively. It was significantly different between the treatment group and the control group （P〈0.01）. Conclusion： Benazepril and amlodipine were the effective and safe drugs in treatment of primary hypertension. The antihypertensive effect is obvious, and they are worthy of being recommended.