脑钠肽在慢性心功能不全诊治的临床观察

目的：评价脑钠肽在慢性心功能不全过程中的诊治效果，探讨其临床适用性。方法：选择从2012年3月至2013年3月于我院就诊的82例心功能不全患者作为实验组，另选择同期的80例健康体检者作为对照组，分析实验组和对照组人员的脑钠肽的浓度，以及实验组患者经过治疗后的脑钠肽浓度变化情况，所有人员同时给予超声心动并观察实验组血浆脑钠肽浓度与左室射血分数及心功能分级之间的关系。结果：实验组患者的血浆脑钠肽浓度明显高于对照组人员，差异有统计学意义（P〈0．05）；实验组患者治疗前后血浆脑钠肽浓度有明显改变，差异也有统计学意义（P〈0．05）；心功能和左室射血分数不同分级之间的血浆脑钠肽浓度也不同，各级差异有明显统计学意义（P〈0．05）；脑钠肽浓度的不同参考值测定的灵敏度和特异性也不同。结论：脑钠肽在慢性心功能不全的诊治过程中有重要价值，为临床心功能的判断可以提供较为敏感的指示，适合临床长期推广应用。

Application of Brain Natriuretic Peptide in Diagnosis and Treatment of Chronic Heart Failure

Objective： To analyze the value ofNT-pro BNP in diagnosis and treatment of chronic heart failure. Methods： 82 cases of patients with heart failure were selected in our hospital from March 2012 to March 2013 as the experimental group, while another 80 healthy people as a control group. Then we analyzed brain natriuretic peptide concentration in the experimental group and a control group, and brain natriuretic peptide concentration changes after patients of the experimental group were treated, all staff were given echocardio- graphy and then observed the relationship between the experimental group brain natriuretic peptide concentration and left ventricular ejec- tion fraction and cardiac function. Results： Brain natriuretic peptide concentration of patients in experimental group was significantly higher than the control group, the difference was statistically significant （P 〈0.05）; significant changes in brain natriuretic peptide concen- tration in the experimental group before and after treatment, the difference was statistically significant （P 〈0.05）; cardiac function and left ventricular ejection fi＇action between the different classification of brain natriuretic peptide concentration, at all levels of the difference was statistically significant （P 〈0.05）; brain natriuretic peptide concentration reference value determination of the sensitivity and speci- ficity. Conclusion： Brain natriuretic peptide has an important meaning in the diagnosis and treatment of chronic heart failure.