Effects of Systemic Kainic Acid Administration on Regional Na+, K+-ATPase Activity in Rat Brain |
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| Authors: | L. Sztriha,F. Joó ,L. Dux&dagger ,Zsuzsanna Bö ti |
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| Affiliation: | Department of Pediatrics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary;Institute of Biophysics, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary;Institute of Biochemistry, and Institute of Anatomy, University Medical School, Szeged, Hungary |
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| Abstract: | Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a subsequent decrease in enzyme activity. The elevation in Na+,K+-ATPase activity was accompanied by an increase in the Na+ content and a decrease in the K+ content. These changes are presumed to occur because of repeated discharges and excessive prolonged depolarization in response to kainic acid. The decreases in Na+,K+-ATPase activity 6 and 24 h following kainic acid treatment coincide with neuropathological damage and edema formation, mainly in the hippocampus and thalamus. |
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| Keywords: | Na+,K+-ATPase Water content Sodium content Potassium content Kainic acid Rats |
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