Regulation of rRNA gene number in Drosophila melanogaster: new aspects resulting from the use of free duplications期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Regulation of rRNA gene number in Drosophila melanogaster: new aspects resulting from the use of free duplications

Authors:	La Volpe A La Mantia G Gargiulo G Malva C

Institution:	(1) Istituto di Biologia Generale e Genetica, Università di Napoli, Via Mezzocannone 8, I-80134 Naples, Italy;(2) International Institute of Genetics and Biophysics, CNR, Via Marconi 10, I-80125 Naples, Italy;(3) Present address: Department of Biology, Unversity of Rochester, 14627 Rochester, NY, USA

Abstract:	Summary We have isolated a bobbed (bb) mutant on the free duplication Dp(1; f)122bb ⁺ and we have measured the rDNA content of the bb ⁺ and the bb loci in genetic combinations in which none of the phenomena involved in the change of the rDNA redundancy occurs. We have also measured the rDNA content of the two bb loci carried by the free duplications in two different genetic combinations: (1) $\widehat{{\text{XX}}}{\text{NO}}^ - /{\text{Dp}}122bb^ +$ and $\widehat{{\text{XX}}}{\text{NO}}^ - /{\text{Dp}}122bb$ females in which there are two attached X chromosomes completely deleted for the nucleolus organizer (NO) regions and there-fore the only rDNA is contributed by the free duplication; (2) X/Dp122bb ⁺ and X/Dp122bb males, in which there are two bb loci, one on the X chromosome and the other on the X free duplication.The bb ⁺ and the bb duplications produced an overall increase of the rDNA content in the two genetic conditions tested.These results are not in favour of both a cis and trans effect of the regulator locus (cr ⁺ locus) hypothesised as being involved in the disproportionate replication of rRNA genes.

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