| Frequency and Absolute Number of FoxP3^＋ Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection |
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| 作者姓名： | Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun XING Bao-yun FU Chun-bao ZHOU Xi-cheng WANG Hao WU Fu-Sheng WANG |
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| 作者单位： | 1.Research Center of Biological Therapy，Beijing Institute of Infectious Diseases，Beijing 302 Hospital，100 Xi Si Huan Middle Road，Beijing 100039，China; 2. Postgraduate Team，Military Postgraduate Medical College，Beijing 100853，China;3. Department of Infectious Diseases，Beijing You-An Hospital Affiliated to Capital University of Medical Science，Beijing 100054，China |
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| 基金项目： | The National Outstanding Youth Foundation of China （30525042）, National 973 project of China （ 2006CB504201, 2006CB504205 ） |
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| 摘 要： | CD4 CD25 Regulatory T cells (Treg) have been found to down-regulate immune activation in HIV-1 infection. However,whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue,we enumerated the Treg absolute counts and frequency in 75 antiviral-nave HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition,with disease progression indicated by CD4 T-cell absolute counts,circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased,suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection. Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus,our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection,influencing the disease progression.
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| 关 键 词： | T细胞 艾滋病 艾滋病病毒侵染 疾病进展 频率 数量 病毒复制 |
| 文章编号： | 1674-0769（2007）06-501-08 |
| 收稿时间： | 2007-08-14 |
| 修稿时间： | 2007-10-11 |
Frequency and Absolute Number of FoxP3 Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection |
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| Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun XING Bao-yun FU Chun-bao ZHOU Xi-cheng WANG Hao WU Fu-Sheng WANG.Frequency and Absolute Number of FoxP3 Regulatory T Cells Correlate with Disease Progression of Chronic HIV-1 Infection[J].中国病毒学(英文版),2007,22(6):501-508. |
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| Authors: | Jun-liang FU Fu-biao KANG Yan-mei JIAO Shao-jun XING Bao-yun FU Chun-bao ZHOU Xi-cheng WANG Hao WU Fu-Sheng WANG |
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| Abstract: | CD4 CD25 Regulatory T cells (Treg) have been found to down-regulate immune activation in HIV-1 infection. However, whether the depletion of Treg benefits to the disease status of HIV infection remains undefined. To address this issue, we enumerated the Treg absolute counts and frequency in 75 antiviral-na(i)ve HIV-1-infected individuals in this study. It was found that HIV-infected patients displayed a significant decline in Treg absolute counts but a significant increase in Treg frequency. In addition, with disease progression indicated by CD4 T-cell absolute counts, circulating Treg frequency gradually increased; while Treg absolute counts were gradually decreased, suggesting that the alteration of Treg number closely correlated with disease progression in HIV infection.Functional analysis further showed that Treg efficiently inhibit both CD4 and CD8 T cell proliferation in vitro. Thus, our findings indicates that Treg actively participate in pathogenesis of chronic HIV infection,influencing the disease progression. |
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| Keywords: | T-Lymphocytes HIV Infections Tolerance/Suppression/Anergy Proliferation |
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