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Pair-wise linear and 3D nonlinear relationships between the liver antioxidant enzyme activities and the rate of body oxygen consumption in mice |
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| Authors: | Muradian Khachik K Utko Natalie A Mozzhukhina Tatyana G Litoshenko Alexander Y Pishel Irina N Bezrukov Vladislav V Fraifield Vadim E |
| Affiliation: | * Department of Physiology, Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine † Department of Molecular Biology, Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev, Ukraine ‡ Department of Clinical Pharmacology, Center for Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel |
| Abstract: | Relationships between the rate of body oxygen consumption (VO2) and the liver key antioxidant enzyme activities were assessed in female CBA mice. The pair-wise linear regression and correlation demonstrated significant correlative links between VO2 and activity of catalase (CAT). Nonlinear 3D plotting revealed a complementary pattern of CAT and glutathione peroxidase (GP) relation. CAT activity was elevated in mice with proportionally high VO2 and superoxide dismutase (SOD), whereas GP activity was high in animals with low or disproportional VO2 and SOD. |
| Keywords: | Body oxygen consumption Superoxide dismutase Catalase Glutathione peroxidase Liver Mice Free radicals |
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