Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line,WIF-B |
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| Authors: | Sergio?A?Gradilone,Pamela?S?Tietz,Patrick?L?Splinter,Raúl?A?Marinelli,Nicholas?F?LaRusso mailto:larusso.nicholas@mayo.edu" title=" larusso.nicholas@mayo.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author |
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| Affiliation: | 1.Instituto de Fisiología Experimental,Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario,Argentina;2.Center for Basic Research in Digestive Diseases,Mayo Medical School, Clinic and Foundation,Rochester,USA |
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| Abstract: | ![]()
Background Recent data suggest that canalicular bile secretion involves selective expression and coordinated regulation of aquaporins (AQPs), a family of water channels proteins. In order to further characterize the role of AQPs in this process, an in vitro cell system with retained polarity and expression of AQPs and relevant solute transporters involved in bile formation is highly desirable. The WIF-B cell line is a highly differentiated and polarized rat hepatoma/human fibroblast hybrid, which forms abundant bile canalicular structures. This cell line has been reported to be a good in vitro model for studying hepatocyte polarity. |
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