Cosmid-derived markers anchoring the bovine genetic map to the physical map |
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| Authors: | L Ferretti B G D Urquhart A Eggen I Olsaker B Harlizius B Castiglioni A Mezzelani S Solinas Toldo U Thieven Y Zhang A L G Morgan V M Teres M Schwerin I Martin-Burriel B P Chowdhary G Erhardt I J Nijman E P Cribiu W Barendse H Leveziel R Fries J L Williams |
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| Institution: | (1) IDVGA-CNR, Milan, 20133, Italy, IT;(2) Roslin Institute (Edinburgh), Roslin, Midlothian, EH25 9PS, Scotland, UK, GB;(3) Laboratoire de Génétique biochimique et de Cytogénétique, INRA-CRJ, Jouy-en-Josas, 78350, France, FR;(4) Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, Oslo, 0033, Norway, NO;(5) Department of Animal Breeding and Genetics, Hannover School of Veterinary Sciences, 30559 Hannover, Germany, DE;(6) Swiss Federal Institute of Technology (ETH), Section Animal Breeding, Zurich, 8092, Switzerland, CH;(7) Dipartimento di Genetica e Microbiologia, via Abbiategrasso 207, Università degli Studi di Pavia, Pavia, 27100, Italy, IT;(8) Department of Molecular Genetics, Research Centre of Animal Production, Rostock-Dummerstorf, Dummerstorf, 18196, Germany, DE;(9) Laboratorio de Genétíca Bioquimica, Facultad de Veterinaria, Zaragoza, E-50013, Spain, ES;(10) Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, S-750 07, Sweden, SE;(11) Justus-Liebig University, Department of Animal Breeding and Genetics, Giessen, 35390, Germany, DE;(12) Lehrstuhl fuer Tierzucht, Technische Universitaet Muenchen-Weihenstephan, Freising, 85350, Germany, DE;(13) Institute of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht, 3508 TD, The Netherlands, NL;(14) CSIRO Division of Tropical Animal Production, University of Queensland, Brisbane, 4072, Australia, AU |
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| Abstract: | The mapping strategy for the bovine genome described in this paper uses large insert clones as a tool for physical mapping
and as a source of highly polymorphic microsatellites for genetic typing, and was one objective of the BovMap Project funded
by the European Union (UE). Eight-three cosmid and phage clones were characterized and used to physically anchor the linkage
groups defining all the bovine autosomes and the X Chromosome (Chr). By combining physical and genetic mapping, clones described
in this paper have led to the identification of the linkage groups corresponding to Chr 9, 12, 16, and 25. In addition, anchored
loci from this study were used to orient the linkage groups corresponding to Chr 3, 7, 8, 9, 13, 16, 18, 19, and 28 as identified
in previously published maps. Comparison of the estimated size of the physical and linkage maps suggests that the genetic
length of the bovine genome may be around 4000 cM.
Received: 1 July 1996 / Accepted: 13 September 1996 |
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