Nuclear receptor FXR,bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Nuclear receptor FXR,bile acids and liver damage: Introducing the progressive familial intrahepatic cholestasis with FXR mutations

Authors:	Marica Cariello Elena Piccinin Oihane Garcia-Irigoyen Carlo Sabbà Antonio Moschetta

Affiliation:	1. Department of Interdisciplinary Medicine, “Aldo Moro” University of Bari, 70124 Bari, Italy;2. INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy;3. National Cancer Center, IRCCS Istituto Oncologico “Giovanni Paolo II”, 70124 Bari, Italy

Abstract:

Keywords:	NR nuclear receptor FXR farnesoid X receptor RXR retinoid X receptor PXR pregnane X receptor VDR Vitamin D receptor TGR5 G protein–coupled bile acid receptor Lrh1 liver receptor homolog 1 Mdr multidrug resistance protein Abcb4 ATP Binding Cassette Subfamily B Member 4 Bsep bile salt export pump Abcb11 ATP Binding Cassette Subfamily B Member 11 BACS BA CoA synthase BAAT SHP small heterodimer partner CYP7A1 cytochrome P450 7A1 MRP2 multidrug related protein 2 DBD DNA binding domain LBD ligand binding domain BA bile acids CA cholic acid CDCA chenodeoxycholic acid OCA obeticholic acid UDCA ursodeoxycholic acid HCC hepatocellular carcinoma IBD inflammatory bowel disease PFIC progressive familial intrahepatic cholestasis ICP cholestasis of pregnancy DIC drug-induced cholestasis BRIC benign recurrent intrahepatic cholestasis FGFR4 fibroblast growth factor receptor 4 FGF15/19 fibroblast growth factor 15/19 TNFα tumor necrosis factor α BAK1 BCL-2 antagonist killer 1 FADD Fas-associated death domain BCL2 B cell lymphoma gene-2 NF-κB nuclear factor-κB HSC hepatic stellate cells CTGF connective tissue growth factor TGF-β transforming growth factor-β PDGF platelet-derived growth factor NTCP sodium (Na)-Taurocholate Cotransporter Protein OSTα/β organic solute transporter OATP organic anion transporting polypeptide Nuclear receptors Bile acids Farnesoid X receptor (FXR) Fibroblast growth factor 19 (FGF19) Cholestasis
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