Interaction between two group IV metals-lead and zirconium-in bone marrow cells ofMus musculus in vivo |
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Authors: | Haimanti Dhir Sujita Ghosh Archana Sharma Geeta Talukder |
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Institution: | (1) Centre for Advanced Study in Cell and Chromosome Research, Department of Botany, University of Calcutta, 35 Ballygunge Circular Road, 700019 Calcutta, India |
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Abstract: | The interaction between two group IV metals, the highly toxic lead and the relatively inactive and low toxic zirconium, was studied in the bone marrow chromosomes ofMus musculus in vivo. Low and high doses of zirconium oxychloride were fed orally to the experimental mice (i) 2 h before, (ii) 2 h after or (iii) together with different doses of lead nitrate. Protection against lead-induced clastogenicity was observed only when the lower dose of zirconium was administered prior to lead. All other combinations gave an additive or synergistic effect as was seen by significant increases in the frequencies of chromosomal aberrations. |
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Keywords: | lead zirconium clastogenicity interaction mouse bone marrow cells |
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