Melt solidification technique: Incorporation of higher wax content in ibuprofen beads |
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Authors: | Ravindra Kamble Manish Maheshwari Anant Paradkar Shivajirao Kadam |
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Institution: | (1) Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038 Pune, Maharashtra State, India;(2) Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, 411038 Pune, Maharashtra State, India |
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Abstract: | The purpose of this study was to achieve incorporation of a higher amount of wax during the preparation of ibuprofen beads
by a melt solidification technique for better integrity and prolonged drug release by using a combination of waxes. A mixture
of cetyl alcohol (CA) and palmitic acid (PA) was used to improve the matrix integrity and drug release. The effect of variables
such as CA, PA, and speed of agitation were studied using 33 factorial design. Yield, crushing strength, and drug release were analyzed using response surface methodology. The in vitro
dissolution test did not show any significant improvement in the drug release. Scanning electron microscopy (SEM) showed that
beads were spherical with a smooth surface, but after dissolution became rough and porous. Differential scanning calorimetry
(DSC) studies showed that different solidification and erosion properties of waxes are responsible for the inability of waxes
to retard drug release even at higher concentration. |
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Keywords: | ibuprofen palmitic acid cetyl alcohol melt solidification factorial design |
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