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Establishment and characterization of human bladder cancer cell lines BexBra1, BexBra2, and BexBra4 |
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| Authors: | Camila B Piantino Juliana M Sousa-Canavez Victor Srougi Fernanda Salvadori Raphael Kato Pedro Paulo R Ayres Miguel Srougi Luiz Heraldo Camara-Lopes Gilka Jorge Figaro Gattás Cintia Fridman Fernanda de Toledo Isaque Santana Kátia Ramos Moreira Leite |
| Institution: | 1. Laboratory of Medical Investigation, Urology Department–LIM55, University of Sao Paulo Medical School, S?o Paulo, S?o Paulo, Brazil 2. Genoa Biotechnology SA, Rua Desembargador Eliseu Guilherme 69, 9th floor, 04004-030, S?o Paulo, S?o Paulo, Brazil 3. Laboratory of Medical Investigation, Department of Legal Medicine, Ethics and Occupational Health, Medical School, University of S?o Paulo Medical School, S?o Paulo, S?o Paulo, Brazil 4. Rua Desembargador Eliseu Guilherme 69, 9th floor 04004-30, S?o Paulo, Brazil |
| Abstract: | Bladder cancer (BC) is the fourth most common cancer in the USA. In Brazil, BC represents 3% of the total existing carcinomas in the population and represents the second highest incidence among urological tumors. The majority of bladder cancer cell lines available were derived from Caucasians and established in the seventies or eighties. Thus, neoplasia development in these cells likely occurred in environment conditions vastly different than today. In the present study, we report the establishment and characterization of three Brazilian bladder cancer cell lines (BexBra1, BexBra2, and BexBra4). These cell lines may be helpful for dissecting the genetic and epigenetic aspects that trigger the progression of BC. Moreover, the development of a Brazilian representative of the disease will allow us to investigate the potential inter-racial differences of malignancy-associated phenotypes in bladder cancer. |
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