Five labdane diterpenoids from the seeds of Aframomum zambesiacum |
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| Authors: | Kenmogne Marguerite Prost Elise Harakat Dominique Jacquier Marie-José Frédérich Michel Sondengam Lucas B Zèches Monique Waffo-Téguo Pierre |
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| Affiliation: | Department of Chemistry, Faculty of Science, University of Dschang, Box 67, Dschang, Cameroon. |
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| Abstract: | Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM. |
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| Keywords: | Aframomum zambesiacum Zingiberaceae Labdane diterpenoids Antiplasmodial activity Plasmodium falciparum |
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