琥珀酸发酵研究进展*

琥珀酸在化工和食品行业应用广泛。与传统化学方法相比，微生物发酵法生产琥珀酸具有诸多优点：生产成本具有竞争力；利用可再生的农业资源包括二氧化碳作为原料，避免了对石化原料的依赖；减少了化学合成工艺对环境的污染。主要介绍产琥珀酸微生物的来源和育种，代谢途径和发酵调控机制以及产品回收工艺的进展。

RESEARCH PROCESS IN PRODUCTION OF SUCCINIC ACID BY FERMENTATION

Succinic acid is widely used in the field of chemistry and food proces s. Compared to the traditional chemical synthesis, succinic acid production by fermentation has some benefits. The new process with competitive cost uses rene wable agricultural resources including green house gas CO 2 instead of fossil f uels and reduces pollution from chemical synthesis. In this article, research progr e ss in production of succinic acid by fermentation such as microorganisms, metabo lic pathways and its regulation, fermentation and isolation are briefly reviewed .