IKKalpha at the crossroads of inflammation and metastasis |
| |
Authors: | Affara Nesrine I Coussens Lisa M |
| |
Institution: | Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA. |
| |
Abstract: | The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. This leads to repression of maspin, a critical suppressor of metastasis, and thus commits malignant prostatic epithelial cells to a metastatic fate. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|