| 甲状腺激素对小鼠免疫功能的调节作用 |
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| 引用本文： | 唐美仪 董再珍. 甲状腺激素对小鼠免疫功能的调节作用[J]. 生理学报, 1991, 43(1): 60-66 |
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| 作者姓名： | 唐美仪 董再珍 |
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| 作者单位： | 曲阜师范大学生物系 曲阜273165(唐美仪)，山东大学生物系 济南250100(董再珍)，山东大学生物系 济南250100(王龙) |
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| 摘 要： | 正常昆明种成年小鼠每天给予一定量的甲状腺激素可使其抗体生成能力、淋巴细胞转化能力、迟发型超敏反应和巨噬细胞的吞噬功能明显增强,外周血成熟 T 细胞数量亦明显增加。而每天给予抗甲状腺药物则使其抗体生成能力、淋巴细胞转化能力和迟发型超敏反应明显降低。切除甲状腺亦使抗体生成能力下降。这些结果提示甲状腺激素参与免疫功能的生理性调节。
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| 关 键 词： | 甲状腺激素 小鼠 免疫调控 |
IMMUNOREGULATORY ROLE OF THYROID HORMONE |
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| TANG MEI-YI. IMMUNOREGULATORY ROLE OF THYROID HORMONE[J]. Acta Physiologica Sinica, 1991, 43(1): 60-66 |
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| Authors: | TANG MEI-YI |
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| Affiliation: | Department of Biology, Qufu Normal University. |
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| Abstract: | The immunoregulatory role of thyroid hormone was investigated in mice weighing 20-30 g. The experimental results showed that the antibody production, transformation of lymphocytes, DTH response (delayed-type hypersensitivity response) and phagocytosis of the peritoneal macrophages were all markedly enhanced when the animals were fed with a daily dose of 2 mg thyroid hormone for 14-18 days. The number of mature T cells in peripheral blood was also increased significantly by the thyroid hormone. When mice were administered with antithyroid drug (methylthiouracil), the antibody production, the transformation of lymphocytes and DTH response were inhibited. Thyroidectomy could also suppress the antibody production. The results suggest that thyroid hormone is involved in the regulation of immune function. |
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| Keywords: | thyroid hormone mouse immunoregulatio(?) |
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