长效干扰素研究进展

干扰素是一类多功能细胞因子，是由哺乳动物细胞受到适宜刺激产生的一种微量的、具高度生物学活性的蛋白质，具有抵抗病毒感染、抑制肿瘤生长和调节机体免疫功能的作用。干扰素α血浆半衰期短而丙型和乙型肝炎治疗周期长，影响了患者的依从性。目前延长蛋白药物半衰期的方法主要有化学修饰、蛋白融合、定点突变技术联合和改造药物制剂释放系统，随着又一新型长效干扰素ZALBIN即将上市，长效干扰素再次成为医药行业的聚焦点。现针对干扰素α长效制剂中的最新研究进展进行综述。

The Advance in Long Effect Interferon Reserch

Interferons are a class of cytokines that play key roles in the regulation of cell growth and differentiation via activation of a cascade of intracellular pathways and represented the functions of antiviral, immunomodulatory, and antiproliferative effects，which are synthesized and secreted by somatic cells of all mammalian species. Interferon alpha (IFN-α) are used in clinic to treat a variety of viral diseases and cancers. Howerver，the short circulating half-life of IFN-α necessitates frequent administration to patients which limits the broader usage. The methods of prolonging the half-life of protein drug in common use are chemical modification, albumin fusion technology, analog construction and combination with drug delivery system. Herein the method of prolonging the half-life of IFN-α in the above-mentioned of the latest research methods were reviewed.