| 重组人骨形态发生蛋白-7表达系统研究进展 |
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| 引用本文： | 安新玲,韩金祥,王世立. 重组人骨形态发生蛋白-7表达系统研究进展[J]. 生物技术通讯, 2009, 20(6): 846-848,873. DOI: 10.3969/j.issn.1009-0002.2009.06.027 |
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| 作者姓名： | 安新玲 韩金祥 王世立 |
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| 作者单位： | 山东省医药生物技术研究中心,卫生部生物技术药物重点实验室,山东济南250062 |
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| 摘 要： | 骨形态发生蛋白-7（BMP-7）在胚胎发育、肾脏保护、骨形成、代谢、再生等各个方面发挥着重要的作用,现已进入了临床应用阶段。我们简要综述了重组人BMP-7（rhBMP-7）的原核表达系统及真核表达系统,并对各表达系统的优缺点进行了分析。
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| 关 键 词： | 骨形态发生蛋白-7 大肠杆菌表达系统 毕赤酵母表达系统 CHO细胞表达系统 腺病毒 |
Progress of Expression System of Recombinant Human Bone Morphogenetic Protein-7 |
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| Affiliation: | A N Xin-Ling, HA N Jin-Xiang, WA NG Shi-Li( Shangdong Medicinal Biotechnology Center, Key Laboratory for Biotech-Drugs of Ministry of Health, Jinan 250062, China) |
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| Abstract: | Bone morphogenetic protein-7（BMP-7） plays important roles in fetal development, renoprotection, bone formation, bone metabolism, bone regeneration, and so on. It has been used clinically. In this article, the expression systems of recombinant human BMP-7 were introduced, including the bacterial expression system and eukaryotic expression system. Meanwhile, each system was compared with others in the merit and demerit. |
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| Keywords: | bone morphogenetic protein-7 bacterial expression system Pichia expression system CHO cells expression system adenovirus |
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