FANCP/SLX4: A Swiss army knife of DNA interstrand crosslink repair |
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| Authors: | Kelly E Cybulski Niall G Howlett |
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| Institution: | Department of Cell and Molecular Biology; University of Rhode Island; Kingston, RI USA |
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| Abstract: | Fanconi anemia (FA) is a rare genetic disease characterized by congenital abnormalities, bone marrow failure and heightened cancer susceptibility. The FA proteins are known to function in the cellular defense against DNA interstrand crosslinks (ICLs), a process that remains poorly understood. A recent spate of discoveries has led to the identification of one new FA gene, FANCP/SLX4, and two strong candidate FA genes, FAN1 and RAD51C. In this perspective we describe the discovery of FANCP/SLX4 and discuss how these new findings collectively refine our understanding of DNA ICL repair.Key words: Fanconi anemia, DNA repair, ubiquitin, FANCP/SLX4, DNA interstrand crosslink repair |
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