IL9 maps to mouse chromosome 13 and human chromosome 5 |
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| Authors: | Beverly A Mock Marianne Krall Christine A Kozak Muriel N Nesbitt O Wesley McBride Jean-Christophe Renauld Jacques Van Snick |
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| Institution: | (1) Laboratory of Genetics, National Cancer Institute, 20892 Bethesda, MD, USA;(2) Laboratory of Biochemistry, National Cancer Institute, 20892 Bethesda, MD, USA;(3) Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, 20892 Bethesda, MD, USA;(4) Department of Biology, University of California at San Diego, 92093 La Jolla, CA, USA;(5) Unit of Experimental Medicine, International Institute of Cellular and Molecular Pathology, Université Catholique de Louvain, Louvain, Belgium;(6) Ludwig Institute for Cancer Research, Brussels Branch, B-1200, Brussels, Belgium;(7) Bldg. 37, Rm. 2B08, NCI, NIH, 20892 Bethesda, MD, USA |
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| Abstract: | Mouse and human cDNA clones encoding the T-cell and mast cell growth factor P40, now designated IL-9, were used to identify DNA restriction fragment length polymorphisms (RFLPs) in sets of somatic cell hybrids and between inbred strains of mice and interspecific backcross progeny. Segregation of mouse and human chromosomes among somatic cell hybrids indicated a location on mouse chromosome 13 and human chromosome 5. RFLPs were identified among inbred strains of mice. Analysis of chromosome 13 alleles for Tcrg, Dhfr, and Il-9 in an interspecific cross between Mus musculus and NFS/N or C58/J mice indicates that IL-9 is distal to Tcrg and Proximal to Dhfr. |
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