| 乳腺癌中Survivin和VEGF的表达 |
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| 引用本文： | 王书昌 杨学伟 张玉玲 张昊. 乳腺癌中Survivin和VEGF的表达[J]. 现代生物医学进展, 2011, 11(21): 4159-4162 |
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| 作者姓名： | 王书昌 杨学伟 张玉玲 张昊 |
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| 作者单位： | 1. 哈尔滨市第二医院 黑龙江哈尔滨150056
2. 哈尔滨医科大学附属二院 黑龙江哈尔滨150086 |
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| 摘 要： | 目的:研究抗凋亡蛋白Survivin,血管内皮生长因子VEGF在乳腺癌中的表达情况,探讨二者的表达与乳腺癌侵袭的关系以及二者之间的联系。从而为临床诊断和治疗乳腺癌提供参考价值。方法:应用免疫组织化学方法检测Survivin和VEGF在41例乳腺癌标本中和10例正常乳腺组织对照组中的表达情况。结果:与对照组相比,乳腺癌中Survivin的阳性表达(68.29%)与VEGF的表达(63.41%)明显升高,且他们的表达与肿瘤的淋巴结转移和c-erBb-2有相关性。而与患者的年龄、临床分期、ER、PR和肿瘤大小无明显相关性。Survivin表达与VEGF表达呈明显正相关(P<0.01)。结论:Survivin(生存素)与VEGF(血管内皮生长因子)的表达在乳腺癌的发生、发展中起重要作用。Survivin的高表达促进了VEGF的促内皮细胞功能。
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| 关 键 词： | 乳腺癌 Survivin VEGF 免疫组化 |
Survivin and VEGF Expressions in Breast Cancer and their Relations |
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| WANG Shu-chang,YANG Xue-wei,ZHANG Yu-ling,ZHANG Hao. Survivin and VEGF Expressions in Breast Cancer and their Relations[J]. Progress in Modern Biomedicine, 2011, 11(21): 4159-4162 |
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| Authors: | WANG Shu-chang YANG Xue-wei ZHANG Yu-ling ZHANG Hao |
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| Affiliation: | 1(1 The second Hospital of Harbin,Heilongjiang,150056; 2 Second Affiliated Hospital of Harbin Medical University Heilongjiang,Harbin 150086) |
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| Abstract: | Objective: To study the expression of Survivin and VEGF in breast carcinoma tissue,and their relation to the invasiveness and metastasis in breast cancer.Methods: Immunohistochemistry was used to detect the expression of Survivin and VEGF in 41 breast cancer and 10 normal breast tissue.Results: The positive expressions of Survivin and VEGF in breast cancer was 68.29% and 63.41% respectively,both higher than that in normal breast tissue(p<0.05).And the expression of Survivin and VEGF was positive related to ... |
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| Keywords: | Breast carcinoma Survivin VEGF Immunohistochemistry |
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