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非小细胞肺癌组织中CDK2 及β-catenin 的表达
引用本文:杨海燕李晓虹张映红. 非小细胞肺癌组织中CDK2 及β-catenin 的表达[J]. 现代生物医学进展, 2011, 11(20): 3897-3898
作者姓名:杨海燕李晓虹张映红
作者单位:厦门大学附属第一医院肿瘤内科 福建 厦门361003
摘    要:目的:观察非小细胞肺癌组织中CDK2及β-catenin的表达,探讨CDK2及β-catenin与肺癌转移的关系。方法:48例非小细胞肺癌患者分为转移组和未转移组。手术取肺癌组织,分别采用实时荧光定量PCR法和western blot法检测脑组织中CDK2及β-catenin蛋白和mRNA的表达。结果:转移组肺癌组织中CDK2及β-catenin蛋白和mRNA的表达明显高于未转移组(P<0.01)。结论:CDK2及β-catenin与肺癌转移有关。

关 键 词:肺癌  CDK2  β-catenin

Expression of CDK2 and3-Catenin in Non Small-Cell Lung Cancer
YANG Hai-yan,LI Xiao-hong,ZHANG Ying-hong. Expression of CDK2 and3-Catenin in Non Small-Cell Lung Cancer[J]. Progress in Modern Biomedicine, 2011, 11(20): 3897-3898
Authors:YANG Hai-yan  LI Xiao-hong  ZHANG Ying-hong
Affiliation:YANG Hai-yan,LI Xiao-hong,ZHANG Ying-hong(Department of medical oncology,The first affiliated hospital of Xiamen University,Fujiang,Xiamen,361003)
Abstract:Objective:To observe the expression of CDK2 and b-catenin in non small-cell lung cancer tissue and to investigate the relationship of CDK2 and b-catenin with metastatic lung cancer.Methods:48 non small-cell lung cancer patient were divided into metachoresis and non metachoresis groups.Real-time FQ-PCR and western blot were applied respectively to detect the protein and mRNA expression of CDK2 and b-catenin in carcinoma tissue.Results:The protein and mRNA expression of CDK2 and b-catenin was obviously higher...
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