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| 地特胰岛素与NPH胰岛素治疗口服降糖药控制不佳的2型糖尿病临床比较研究 | |
| 引用本文： | 杨架林李雪松沈春芳张钰范晓方任凤东. 地特胰岛素与NPH胰岛素治疗口服降糖药控制不佳的2型糖尿病临床比较研究[J]. 现代生物医学进展, 2011, 11(21): 4109-4112 |
| 作者姓名： | 杨架林李雪松沈春芳张钰范晓方任凤东 |
| 作者单位： | 上海瑞金医院集团闵行区中心医院内分泌科 上海201100 |
| 摘 要： | 目的:观察口服降糖药控制不佳的2型糖尿病患者分别加用地特胰岛素和NPH胰岛素治疗24周的有效性和安全性。方法:63例口服降糖药物控制不佳(HbA1c>7%)的2型糖尿病患者随机加用地特胰岛素或鱼精蛋白锌(NPH)胰岛素作为基础胰岛素,每日1次治疗24周,比较两组治疗前后糖化血红蛋白、体重、血脂的变化及低血糖的发生率。结果:两组的糖化血红蛋白、空腹血糖与基线比较均有显著下降,治疗后组间无差异。与NPH胰岛素组比较地特胰岛素组体重增加明显减少,差异有统计学意义。地特胰岛素组治疗期间全部低血糖次数较NPH胰岛素组减少54.69%(P<0.01)。结论:地特胰岛素与NPH胰岛素相比,在有效控制血糖的同时可降低低血糖发生风险,而且有减少体重增加的优势。 |
| 关 键 词： | 2型糖尿病 地特胰岛素 NPH胰岛素 |
A Randomized, Parallel Study Comparing Insulin Detemir with NPH Insulinas Add-on Therapy for Type 2 Diabetes |
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| YANG Jia-lin,LI Xue-song,SHEN Chun-fang,ZHANG Yu,FAN Xiao-fang,Feng-dong,REN feng-dong. A Randomized, Parallel Study Comparing Insulin Detemir with NPH Insulinas Add-on Therapy for Type 2 Diabetes[J]. Progress in Modern Biomedicine, 2011, 11(21): 4109-4112 | |
| Authors: | YANG Jia-lin LI Xue-song SHEN Chun-fang ZHANG Yu FAN Xiao-fang Feng-dong REN feng-dong |
| Affiliation: | YANG Jia-lin,LI Xue-song,SHEN Chun-fang,ZHANG Yu,FAN Xiao-fang,Feng-dong,REN feng-dong(Department of Endocrinology,Minhang Central Hospital,Shanghai,201100,China) |
| Abstract: | Objective: To assess efficacy and safety of insulin detemir or NPH insulin added to oral therapy for type 2 diabetes.Methods: Individuals(n=63) with HbA1c exceed 7% were randomized to addition of once-daily insulin detemir or NPH insulin in a par-allel-group trial.Outcomes assessed included HbA1c,body weight,triglyceride,total cholesterol,LDL-C,HDL-C and risk of hypo-glycemia.Result: After 24 weeks treatment,FPG and HbA1c were both decreased than baseline,but no significantly different between two groups.We... |
| Keywords: | Type 2 diabetes Insulin detemir Insulin NPH |
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