The Role of Platelet Serotonin and Depression in the Acute Coronary Syndrome Population

Platelet serotonin has been associated with depression and coronary arterydisease. Understanding the association between platelet serotonin and depressivesymptoms during acute coronary syndrome (ACS) may explain some of the ACS eventsseen in depressed individuals. The objectives were to evaluate whether levels ofplatelet serotonin during an ACS event differ between individuals who screenpositive or negative for depressive symptoms and to determine if a linearrelationship exists. In this cross-sectional study, data were collected on 51patients with ACS. Multiple linear regression models were examined. Plateletserotonin levels were not significantly different between the depressed andnon-depressed groups (β = -4.093 and p = .293); a linear relationship was notfound (β = -.254 and p = .250). In conclusion, a relationship between plateletserotonin and depressive symptoms was not found. It remains unclear if anassociation exists between platelet serotonin levels and depressive symptomsduring hospitalization for ACS.