miR-93 enhances hepatocellular carcinoma invasion and metastasis by EMT via targeting PDCD4 |
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| Authors: | Chunmei Ji Hang Liu Qiang Yin Hui Li Han Gao |
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| Institution: | 1.Department of Clinical Laboratory,People’s Hospital of Weifang,Weifang,People’s Republic of China;2.Department of Interventional Therapy,Yidu Central Hospital of Weifang,Weifang,People’s Republic of China;3.Department of Oncology,People‘s Hospital of Rizhao,Rizhao,People’s Republic of China;4.Department of PIVAS,People’s Hospital of Zhangqiu,Jinan,People’s Republic of China;5.Department of Pathology,Qingdao Municipal Hospital,Qingdao,People’s Republic of China |
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| Abstract: | ObjectivesTo clarify the potential biological function of miR-93 and its related molecular mechanism underlying metastasis in human hepatocellular carcinoma (HCC).ResultsmiR-93 was significantly up-regulated in HCC tissues and was associated with poor 5-year overall survival in HCC patients. Transwell assays showed that over-expression of miR-93 increased HCC cell migration and invasion in vitro. Programmed cell death 4 (PDCD4) was a target gene of miR-93 and miR-93 could down-regulate the expression of PDCD4 by directly targeting its 3′-UTR. The re-expression of PDCD4 could attenuate the HCC cell invasion and migration induced by miR-93, while the knockdown of PDCD4 would promote HCC cell migration and invasion via the epithelial-mesenchymal transition (EMT) pathway.ConclusionsmiR-93 provides new insight into the molecular mechanisms of pathogenesis and progression in HCC and offer a potential therapeutic target for the treatment of HCC patients. |
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