Human mast cells express leptin and leptin receptors |
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Authors: | Jasmien Taildeman Claudina A Pérez-Novo Isabelle Rottiers Liesbeth Ferdinande Anouk Waeytens Veerle De Colvenaer Claus Bachert Pieter Demetter Wim Waelput Katleen Braet Claude A Cuvelier |
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Institution: | 1. Department of Pathology, Ghent University Hospital, Ghent University, Block A, 5th Floor, De Pintelaan 185, 9000, Ghent, Belgium 2. Department of Otorhinolaryngology, Ghent University Hospital, Ghent University, Ghent, Belgium 3. Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent University, Ghent, Belgium 4. Department of Pathology, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium 5. Department of Pathology, Antwerp University Hospital, Antwerp, Belgium 6. School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Australia
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Abstract: | Mast cells are immune cells that produce and secrete a variety of mediators and cytokines that influence various inflammatory
and immune processes. Leptin is a cytokine regulating metabolic, endocrine as well as immune functions via the leptin receptor
which is expressed by many immune cells. However, there are no data about leptin receptor expression in mast cells. Immunohistochemical
and immunofluorescent double stainings showed the expression of leptin and leptin receptors in mast cells in human skin and
several parts of the respiratory, gastrointestinal and urogenital tract. Leptin was expressed in mast cells expressing the
classification marker chymase, whereas a variable expression was observed in tryptase positive mast cells. For leptin receptors,
the expression pattern was tissue dependent and not related to tryptase or chymase expression. Our results demonstrate the
expression of leptin and leptin receptors on mast cells, suggesting paracrine and/or autocrine immunomodulatory effects of
leptin on mast cells. |
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Keywords: | Leptin Leptin receptor Mast cell Mast cell phenotypes |
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