|
|||||
|
|
A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes |
|
| Authors: | Bisaha Sharon N Malley Mary F Pudzianowski Andrew Monshizadegan Hossain Wang Paulina Madsen Cort S Gougoutas Jack Z Stein Philip D |
| Affiliation: | Department of Discovery Chemistry, Bristol-Myers Squibb, Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. |
| Abstract: | The preferred absolute configuration of two series of F(1)F(0)-ATP synthase inhibitors was determined. Although the configuration of the active enantiomer in each series is different, each series presents the same 'triaryl' pharmacophore to the enzyme binding site. |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |