The nuclear transport machinery in Caenorhabditis elegans: A central role in morphogenesis |
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| Authors: | Stephen A. Adam |
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| Affiliation: | 1. Istituto di Biologia e Patologia Molecolari, CNR-Dipartimento di Scienze Biochimiche “Rossi Fanelli”, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy;2. Dipartimento di Biologia e Biotecnologia “C. Darwin”, Sapienza Università di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy;1. Univ Lyon, Université Claude Bernard Lyon 1, ICBMS - UMR CNRS 5246, MEM2, F-69622 Villeurbanne, France;2. Membrane Biophysics and Biophotonics group/MEMPHYS Dept. Biochemistry and Molecular Biology, University of Southern, Denmark;3. Univ Lyon, Université Claude Bernard Lyon 1, Centre de Recherche en Cancérologie de Lyon, F- 69373 Lyon, France |
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| Abstract: | Our full understanding of the various roles for the nuclear transport machinery has come from a variety of model organisms including yeast, nematodes, fruit flies and vertebrates. Using the nematode Caenorhabditis elegans, it has been shown that the karyopherin family of nuclear transporters and the components of the Ran cycle have roles not only in nuclear protein transport, but also in mitotic spindle formation and regulation, and in nuclear envelope assembly. These studies have also demonstrated a role for nuclear transport factors in cellular differentiation and development, particularly for the formation of germ cells. This review highlights the small number of studies in C. elegans that have been critical to our understanding of this important cellular process. |
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